Pharmaceutical



- use in chemotherapy.

Patented June 1 1, 1929.

UNITED' STATES; PAiTENr OFFICE;

mosns "L. cRossLEY,'oF PLA1NFIELD,.NEW JERSEY, Assicuoa T0 CALCO cnEiviIcAI; J coMrAn-Y, or-rouumanoox, NEW-JERSEEJA'CORPORATION or new JERSEY.

' r ARMAcEUTrGAL. I

' No Drawing.

My invention relates particularly to improved pharmaceuticals i which have enhanced economic value and more extended The object of myfinventionis to provide .an improvement in pharmaceuticals, and es-.

peciallyin connection with antipyreticfs and analgesics, whereby, because ofthe synergic admixtures therewith of magnesium compounds, their therapeutic properties are increased or 'potentiated. i I

I have discovered that. the therapeutic effects of pharmaceuticals, and particularly antipyretics and analgesics, may be poten-' tiated by admixture therewith of' magnesium compounds, some of which are, however, more suitable than others, and that the resulting synergic compositions have distinctadvantages both of an economical and medicinal character over the v combined effects of the products used in the compositions. Inother words, by this means less of the drug isrequired to produce-the desired effectand, accordingly, the effective thera peutic dosage may be reduced. Furthermore, I have found, in compositions of this character, that the margin between the toxic effects and the therapeutic efficiency of the drugs is 1 increased and, accordingly, the safety of the medication is enhanced. Another advantage possessed by these synergic products is theincomparatively rapid therapeutic action. They appear to act, more quickly than the drugs used, in the compositions.

While my invention is capable of being carried out in many different ways, for the purpose of illustration 1 shall describe only certain ways of carrying out my invention hereinafter.

For example, my invention may be typified by a composition containing a magnesium compound, for example, a salt such as magnesium chloride, together with a compound of the phenylcinchoninic acid series, the formula for which-is 7 coon The effective therapeutic dosage of phenylcinchoninic acid '(cinchophen), for ex- .Vquininer v "It will ,be' found I that the therapeutic bpplication fild March 24, 1927,, Serial No. 178,152..

ample, can be reduced byapproximately I 30% to 50%.of the doses previously .found necessary. by the presence ofunagnesium chloride used therewith. Ginchoph'en is usually administered in 7 grain tablets.

"I have found, that insteadthereof there can be used effectively a' tablet containing approximately 3 grains of cinclrophen and 4 grams of magnesium chloride. In this manner, the relative proportion of the mag- Y nesium compound to the drug isfnot in any cost than when using phenylcinchoninic acid alone, but, in addition, the toxicity of the efiecti-ve dosage is less and the desired therapeutic effect is secured in a shorter period of 1 time. f This is highly advantageous, especially where the product is administered 'per 0s, and where some time 'must elapse between the admi'nifstration and the arrivalof the drug at the point where its therapeutic effects are manifested. My invention is not limited, however, to any particular method of administration, Also, it will be understood that it is not entirelyfnecessary toadminister the constituents of .the composition in the form of an intimate mixture.

- Instead of the phenylcinchoninic acidas referred to in the above example, I may use other derivatives thereof, as, .for example, salts of phenylcinchoninic acid, or' other dc,-

rivatives such as the 6-methyl-phenylcinchov ninic acid, the esters of phenylcinchoninic acid, the esters of G-methyl-phenylcinchoninic acid, etc. Other antipyretics and analgesics which I may use in this connection are the following:

-Salicylat'es, particularly aspirin; acetanilid; phenacetin; antipyrene, pyramidony properties of these various pharmaceuticals are potentiated and modified in a similar manner, as in the case ofthe use of phenyl cinchoninic acid 'above' referred, to. The

clinical; results obtained by means of these several compositions are of magnitude.- V

,Synergic products of this kind are particularly effective in rheumatic fever, neuralgia',"" neuritis, and other inflammatory conditions, for which compounds of the of a similar order phenylcinchoninic acid series are especially valuable remedies.

The proportions and percentages used herein are merely illustrative of the practical application of my invention and may be varied within wide limits. i 7

While I have described my invention above in detail I wish it to iceunderstood that many changes may be" made therein drug, the therapeutic properties of which Without departing from the spirit of the same. v 1

I claim: a 1. A pharmaceutical product comprising a sy'nergic composition containing a magnesiumi compound and a synthetic aromatic are accentuated by the magnesium compound I 2. A pharmaceutical product comprising ,a synergic composition containing a magnesium compound and a drug containing, a

phenylcinchoninic acid radical, the therapeutic properties of .w'hichcare accentuated by the magnesium compound,

3, A pharmaceutical product comprising a synergic composition containing a magnesium compound and cinchophen, the thera-' peutic properties of which areaccentuated by the magnesium compound. I

4:. A pharmaceutical product comprising a synergic composition containing magnesium chloride and a synthetic aromatic drug, the therapeutic properties of which are accentuated by the magnesium chloride. 5. A pharmaceutical product comprising v 6. A pharniaceutic a syner'gic composition containing magnesium chloride and "cinchophen, the therapeutic properties of which are accentuated l by the magnesimnzchloride.

7. A pharmaceutical productQconuprising a synergic composition containing a magnc'sium compound and an aromatic antipyby the retic, the. antip'yreticv properties of which are increased by the magnesium compound. 8; A pharmaceutical product compr sing a synergiccomposition containing magnesium chloride and an aromatic antipyretic, .r

the antipyretic properties of which are accentuated bythe magnesium chloride.

9.;A pharmaceutical product comprising a synergic composition containing a magnesium comphund and a synthetic aromatic "analgesic the analgesic properties of which are accentuated by the magnesium compound. I

. 10. A pharmaceutical product comprising a synergic composition containing magnesiu m chloride and a synthetic aromatic an,-

algesic, the analgesic properties of which are accentuated by the magnesium chloride.

In testimony that I claim the foregoing,-

I- have hereunto set my hand this 16th day: of March, 1927.

MOSES L. cRossLEY. 

